Tumor microenvironment in gastric cancers
نویسندگان
چکیده
منابع مشابه
RETROSPECTIVE STUDY OF GASTRIC CANCERS IN TEHRAN
ABSTRACT Background: Gastric cancer is one of the most common cancers in our country. Recent studies have shown that adenocarcinoma of the cardia and distal stomach has increased in the past 25 years. However demographic data is lacking in this regard. Methods: This study is a retrospective case series study. All records from 460 consecutive patients who were documented pathologically to have ...
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Abstract While genetic changes are critical for the malignant transformation of epithelial cells, the microenvironment in which the cells reside also governs carcinogenesis. Most tumors arise within a cellular microenvironment characterized by suppressed host immunity, dysregulated inflammation, and increased production of cellular growth and survival factors that induce angiogenesis and inhibi...
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We have profiled, for the first time, an evolving human metastatic microenvironment by measuring gene expression, matrisome proteomics, cytokine and chemokine levels, cellularity, extracellular matrix organization, and biomechanical properties, all on the same sample. Using biopsies of high-grade serous ovarian cancer metastases that ranged from minimal to extensive disease, we show how nonmali...
متن کاملretrospective study of gastric cancers in tehran
abstract background: gastric cancer is one of the most common cancers in our country. recent studies have shown that adenocarcinoma of the cardia and distal stomach has increased in the past 25 years. however demographic data is lacking in this regard. methods: this study is a retrospective case series study. all records from 460 consecutive patients who were documented pathologically to have g...
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All gastric carcinomas are originated from foveolar (stem/basal) cells, in practice. The most important development in this field is the detection of H.pylori’s role in the development of chronic gastritis as an important etiological factor. In most examples, they develop on the ground of intestinal metaplasia and chronic atrophic gastritis, and led by various stages of dysplasia, carcinoma in ...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2020
ISSN: 1347-9032,1349-7006
DOI: 10.1111/cas.14521